Selenocystein

Selenocystein med forkortelserne Sec og Se-Cys er en usædvanlig aminosyre, der findes i adskillige enzymer som glutathion peroxidaser, tetraiodothyronin 5' deiodinaser, thioredoxin reductaser, format dehydrogenaser, glycin reductaser og nogle hydrogenaser.

Selenocystein indsættes ved en UGA-codon (der normalt er et stop-codon) ved en speciel mekanisme, der kaldes "translational recoding".^[1]^[2]

Referencer redigér

^ Driscoll D, Copeland P. "Mechanism and regulation of selenoprotein synthesis". Annu Rev Nutr. 23: 17-40. PMID 12524431.
^ Baranov P.V., Gesteland R.F. and Atkins J.F. (2002). "Recoding: translational bifurcations in gene expression". Gene. 286 (5): 187-201. doi:10.1016/S0378-1119(02)00423-7. PMID 11943474.

[1] Driscoll D, Copeland P. "Mechanism and regulation of selenoprotein synthesis". Annu Rev Nutr. 23: 17-40. PMID 12524431.

[2] Baranov P.V., Gesteland R.F. and Atkins J.F. (2002). "Recoding: translational bifurcations in gene expression". Gene. 286 (5): 187-201. doi:10.1016/S0378-1119(02)00423-7. PMID 11943474.

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