Nicks karriere begyndte da han blev opdaget i en alder af 6 år fisk[[Hospitaler fiski fisk fisk fisk fisk fiskhosDanmark|hos]] en frisør, mens hans mor blev klippet, hvorefter han blev henvist til en professionel show business manager.<ref name="MTV News">[http://www.mtv.com/news/articles/1527894/20060405/jonas_brothers.jhtml MTV: More Blink-182 Than Hanson, It's Time For The Jonas Brothers]</ref><ref>[http://www.ccmmagazine.com/music/artist/jonas_brothers/browseK/ Jonas Brothers – CCMmagazine.com]</ref><ref name="MTV video">[https://www.youtube.com/watch?v=Gd3Hj1cfDKU MTV News: Jonas Brothers]</ref> Han begyndte at optræde på [[Broadway theatre|Broadway]] da han var 7 år gammel.<ref name="Ken Phillips">[http://www.kenphillipsgroup.com/Phillips/jonasbrothers.htm Jonas Brothers: It's About Time]</ref><ref name="Clubhouse">[http://www.clubhousemagazine.com/truelife/interviews/a0001236.cfm Clubhouse Magazine]</ref> Han var med i flere stykker, her i blandt ''[[A Christmas Carol]]'' (i 2000 som Tiny Tim og Scrooge, 8 år), ''[[Annie Get Your Gun (musical)|Annie Get Your Gun]]'' (i 2001 som Little Jake), ''[[Beauty and the Beast]]'' (i 2002 som Chip), og ''[[Les Misérables (musical)|Les Misérables]]'' (i 2003 som Gavroche).<ref name="Clubhouse" /><ref>[http://www.playbill.com/news/article/71258.html Playbill News: Beauty and the Beast Becomes 8th Longest-Running Show Aug. 4]</ref><ref>[http://www.playbill.com/news/article/77733.html Playbill News: Photo Call: Les Misérables: Leading Mann]</ref><ref>[http://www.playbill.com/celebritybuzz/whoswho/biography/12193.html Playbill Biography: Nicholas Jonas]</ref> Efter at ''Les Misérables'' lukkede, var han med i ''[[The Sound of Music]]'' (som Kurt) ved [[Paper Mill Playhouse]].<ref>[http://web.playbill.com/news/article/81717.html Playbill News: Meg Bussert Joins Paper Mill Sound of Music; Complete Casting Announced]</ref>
Den 21. juni, 2010 fik Jonas sin West End dubut i forestillingen ''Les Misérables'' for anden gang, men denne gang i rollen som [[Marius Pontmercy]]. <ref name="oceanup2">{{cite web|url=http://www.oceanup.com/2010/05/27/nick-jonas-les-miserables-marius-role |title=Nick Jonas Les Miserables Marius ROLE |publisher=oceanUP.com |date=2010-05-27 |accessdate=2010-09-06}}</ref> Jonas was originally supposed to play the role for only three weeks, but was able to extend his run until July 24, 2010 because of changes in the Jonas Brothers tour schedule.<ref>{{cite web|url=http://www.broadwayworld.com/article/Ramin_Karimloo_Confirmed_As_Enjolras_In_Concert_LES_MISERABLES_Nick_Jonas_Extends_West_End_Run_20100706 |title=Ramin Karimloo Confirmed As Enjolras In Concert LES MISERABLES; Nick Jonas Extends West End Run 2010/07/06 |publisher=Broadwayworld.com |date= |accessdate=2010-09-06}}</ref> He also appeared in the 25th Anniversary Concert at [[The 02]] Arena on October 3, 2010, again playing the role of Marius Pontmercy.<ref>{{cite news| url=http://www.dailymail.co.uk/tvshowbiz/article-1282008/Jonas-Brothers-star-Nick-make-West-End-debut-Les-Miserables.html?ito=feeds-newsxml | location=London | work=Daily Mail | title=Jonas Brothers star Nick to make West End debut in Les Miserables | first=Baz | last=Bamigboye | date=28. maj 2010}}</ref>
