CDKN2A

CDKN2A
Tilgængelige strukturer
PDB	Ortologsøgning: PDBe RCSB
Liste over PDB-idkoder
	2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
Identifikatorer
Aliaser	CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF.
External IDs	OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A
Genetisk-relaterede sygdomme
	melanoma-pancreatic cancer syndrome, mucosal melanoma, modermærkekræft, familial atypical multiple mole melanoma syndrome
Genontologi
Molekylær funktion	• NF-kappaB binding; • GO:0001948, GO:0016582 proteinbinding; • cyclin-dependent protein serine/threonine kinase inhibitor activity; • protein kinase binding; • RNA binding; • DNA binding; • p53 binding; • transcription factor binding; • MDM2/MDM4 family protein binding; • ubiquitin-protein transferase inhibitor activity; • SUMO transferase activity; • disordered domain specific binding; • GO:0090645, GO:0061637 ubiquitin ligase inhibitor activity;
Cellulær komponent	• cytoplasma; • cytosol; • senescence-associated heterochromatin focus; • Cellekerne; • nuclear body; • nucleoplasm; • Kernelegeme; • Mitokondrie; • GO:0009327 protein-containing complex;
Biologisk proces	• positive regulation of smooth muscle cell apoptotic process; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • replicative senescence; • G1 phase; • negative regulation of cell-matrix adhesion; • cellular senescence; • negative regulation of cell growth; • positive regulation of cellular senescence; • positive regulation of macrophage apoptotic process; • cell cycle; • Ras protein signal transduction; • negative regulation of phosphorylation; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • negative regulation of cell population proliferation; • G1/S transition of mitotic cell cycle; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle; • GO:0097285 Apoptose; • regulation of G2/M transition of mitotic cell cycle; • GO:0009373 regulation of transcription, DNA-templated; • regulation of protein stability; • negative regulation of immature T cell proliferation in thymus; • regulation of protein export from nucleus; • negative regulation of protein kinase activity; • negative regulation of proteolysis involved in cellular protein catabolic process; • protein K63-linked ubiquitination; • positive regulation of signal transduction by p53 class mediator; • somatic stem cell division; • protein stabilization; • protein polyubiquitination; • positive regulation of protein sumoylation; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • autophagy of mitochondrion; • apoptotic mitochondrial changes; • regulation of protein targeting to mitochondrion; • protein destabilization; • negative regulation of ubiquitin-protein transferase activity; • positive regulation of apoptotic process; • rRNA processing; • negative regulation of ubiquitin-dependent protein catabolic process; • mitochondrial depolarization; • positive regulation of DNA damage response, signal transduction by p53 class mediator; • negative regulation of B cell proliferation; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of apoptotic DNA fragmentation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of protein localization to nucleus; • protein sumoylation; • GO:1901313 positive regulation of gene expression; • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity; • amyloid fibril formation; • negative regulation of protein neddylation;
	Sources:Amigo / QuickGO
RNA-udtryksmønster
	; ; ; ;
	Flere henvisninger til udtrykdata
Ortologer
	1029
	12578
	ENSG00000147889
	ENSMUSG00000044303
	P42771; Q8N726
	P51480; Q64364
NM_000077; NM_001195132; NM_058195; NM_058196; NM_058197;
	NM_001363763
	NM_001040654; NM_009877
NP_000068; NP_001182061; NP_478102; NP_478104; NP_001350692;
	NP_478102.2
	NP_001035744; NP_034007; NP_034007.1
	Wikidata
Vis/Rediger Menneske	Vis/Rediger Mus

CDKN2A, også kendt som cyclin-dependent kinase Inhibitor 2A, er et gen, der i mennesker er placeret i kromosom 9, bånd p21.3.^[4] Det er allestedsnærværende udtrykt i mange typer væv og celler.^[5] Genet koder for to proteiner, heriblandt p16 (eller p16INK4a) og p14arf.^[6] Begge fungerer som tumorsuppressorer ved at regulere cellecyklussen.