I 2016 medvirkede Dempsey i [[Universal Pictures]]-filmen ''[[Bridget Jones' Baby]]'' med [[Renée Zellweger]] og [[Colin Firth]],<ref>{{cite news|last1=Jaafar|first1=Ali|title=Patrick Dempsey Joining 'Bridget Jones's Baby' For Working Title|url=https://deadline.com/2015/09/patrick-dempsey-bridget-jones-baby-working-title-renee-zellweger-colin-firth-1201519501/|access-date=September 13, 2015|work=deadline.com|date=September 9, 2015}}</ref> og optrådte i 2018 [[Epix]]-tv-miniserien ''[[The Truth About the Harry Quebert Affair]]''.<ref>{{cite web|last1=Bacle|first1=Ariana|title=Patrick Dempsey Sets TV Return With 'The Truth About the Harry Quebert Affair' Adaptation|url=https://ew.com/tv/2017/08/15/patrick-dempsey-truth-about-harry-quebert-affair/|website=[[Entertainment Weekly]]|access-date=April 26, 2018|language=en|date=August 15, 2017}}</ref>
Den 4. februar 2020 fik Dempsey hovedrollen i [[CBSColumbia Broadcasting System|CBS']] politiske dramapilot ''Ways & Means'', hvor han skulle spille en kongresleder.<ref>{{cite web|last=Andreeva|first=Nellie|title=Patrick Dempsey To Star In CBS Political Drama Pilot 'Ways & Means' From Ed Redlich, Mike Murphy & PatMa|url=https://deadline.com/2020/02/patrick-dempsey-star-cbs-political-drama-pilot-ways-means-ed-redlich-mike-murphy-patma-1202850622/|website=[[Deadline Hollywood]]|access-date=February 6, 2020|language=en|date=February 4, 2020}}</ref> Den skulle oprindeligt være sendt i 2020-21-tv-sæsonen, men piloten blev sat på pause til den følgende tv-sæson på grund af [[Coronaviruspandemien|COVID-19 pandemien]]. CBS udsendte den færdige pilot i maj 2021.<ref>{{Cite web|last=Andreeva|first=Nellie|date=May 14, 2021|title=CBS Pilots Update: ‘Ways & Means’, Sarah Cooper/Cindy Chupack & ‘Welcome To Georgia’ Not Moving Forward|url=https://deadline.com/2021/05/cbs-pilots-ways-means-sarah-cooper-cindy-chupack-welcome-to-georgia-dead-patrick-dempsey-1234757258/|access-date=June 4, 2021|website=[[Deadline Hollywood]]}}</ref> I januar 2021 blev det annonceret, at Dempsey ville genoptage sin rolle i ''Enchanted''-efterfølgeren, ''[[Disenchanted]]'', som startede optagelser samme forår.<ref>{{cite web |title=Patrick Dempsey returning alongside Amy Adams for 'Enchanted' sequel, 'Disenchanted' |url=https://www.goodmorningamerica.com/culture/story/patrick-dempsey-returning-alongside-amy-adams-enchanted-sequel-75231103 |website=Good Morning America |access-date=January 15, 2021}}</ref>
==Motorløb==
[[Image:PatrickDempsey2008Rolex24OfDaytona.jpg|thumb|right|upright|Dempsey i 2008 ved [[Rolex 24 Hours of Daytona]]]]
