[[Plutark]], [[Arrian]], [[Diodorus Siculus]], [[Justin]] og andre af oldtidens historikere gengiver [[rygte]]r om, at [[Alexander den Store]] kunne være død som følge af en [[forgiftning]] med ophav i Styx' vand, der blev anset som så ætsende, at det kunne opløse en hvilken som helst beholder andet end én, der var fremstillet af [[Hov (negl)|hestehoverhestehove]].<ref>"Plutarch, Arrian, Diodorus, Justin, and other ancient historians report that rumors of poisoning arose after the death of Alexander in Babylon in 323 B.C. Alexander’s close friends suspected a legendary poison gathered from the River Styx in Arcadia, so corrosive that only the hoof of a horse could contain it", hentet fra: http://www.ancient.eu/article/272/</ref> Nyere forskning bemærker også, at Alexanders [[symptom]]er under sygdommen sammenfaldt med det, guderne angiveligt risikerede ved en forgiftning med vand fra Styx. Blandt andet mistede han stemmen.<ref>"Notably, some of Alexander's symptoms and course of illness seem to match ancient Greek myths associated with the Styx. He even lost his voice, like the gods who fell into a coma-like state after drinking from the river", hentet fra: http://www.telegraph.co.uk/news/worldnews/europe/greece/7924855/Alexander-the-Great-poisoned-by-the-River-Styx.html</ref>
